Details

Autor(en) / Beteiligte

• Nadal-Nicolás, Francisco M
• Kunze, Vincent P
• Ball, John M
• Peng, Brian T
• Krishnan, Akshay
• Zhou, Gaohui
• Dong, Lijin
• Li, Wei

Titel

True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

Ist Teil von

• eLife, 2020-05, Vol.9

Ort / Verlag

England: eLife Science Publications, Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Color, an important visual cue for survival, is encoded by comparing signals from photoreceptors with different spectral sensitivities. The mouse retina expresses a short wavelength-sensitive and a middle/long wavelength-sensitive opsin (S- and M-opsin), forming opposing, overlapping gradients along the dorsal-ventral axis. Here, we analyzed the distribution of all cone types across the entire retina for two commonly used mouse strains. We found, unexpectedly, that 'true S-cones' (S-opsin only) are highly concentrated (up to 30% of cones) in ventral retina. Moreover, S-cone bipolar cells (SCBCs) are also skewed towards ventral retina, with wiring patterns matching the distribution of true S-cones. In addition, true S-cones in the ventral retina form clusters, which may augment synaptic input to SCBCs. Such a unique true S-cone and SCBC connecting pattern forms a basis for mouse color vision, likely reflecting evolutionary adaptation to enhance color coding for the upper visual field suitable for mice's habitat and behavior.