BMC neuroscience, 2020-07, Vol.21 (1), p.31-18, Article 31
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity
- Ist Teil von
- BMC neuroscience, 2020-07, Vol.21 (1), p.31-18, Article 31
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2020
- Quelle
- 2022 ECC(Springer)
- Beschreibungen/Notizen
- Parkinson's disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person's risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases. We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detected 7 and 123 differentially methylated loci (DML) in brain and blood DNA, respectively (p < 0.0001). The comparison of cases with 4+ to 0-2 detectable levels of OGCs, identified 8 and 18 DML in brain and blood DNA, respectively (p < 0.0001). Pathway analyses revealed links to key neurotoxic and neuropathologic pathways related to impaired immune and proinflammatory responses as well as impaired clearance of damaged proteins, as found in the predominantly glial cell population in these environmental exposure-related PD cases. These results suggest that distinct DNA methylation biomarker profiles related to environmental exposures in PD cases with previous exposure can be found in both brain and blood.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-2202eISSN: 1471-2202DOI: 10.1186/s12868-020-00582-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_d9d45d4f80e24a8d888b617f3e8ba273
- Format
- –
- Schlagworte
- Age, Aged, Aged, 80 and over, Analysis, Biomarkers, Brain research, Central nervous system, Deoxyribonucleic acid, Disease susceptibility, DNA, DNA methylation, DNA Methylation - genetics, Emigrants and Immigrants, Environmental toxicology, Epidemiology, Epigenesis, Genetic - genetics, Epigenetic inheritance, Epigenetics, Genes, Genetic research, Genome-Wide Association Study, Genome-wide DNA methylation, Genomes, Genomics, Glia, Glial cells, Herbicides, Humans, Immigrants, Immune clearance, Inflammation, Japan, Methylation, Mitochondrial DNA, Movement disorders, Neurodegenerative diseases, Neuroglia - pathology, Neuroinflammation, Neuronal-glial interactions, Neurotoxicity, Occupational exposure, Organic chlorine compounds, Organochlorine compounds, Organochlorines, Parkinson Disease - genetics, Parkinson's disease, Pathology, Peripheral blood, Pesticides, Plantation work, Plantations, Proteins