Details

Autor(en) / Beteiligte

• Zeng, Yanbo
• Wang, Shirong
• Peng, Hanyang
• Zhao, Weibo
• Chang, Wenjun
• Wang, Hao
• Chen, Huiqin
• Dai, Haofu

Titel

p -Terphenyl and Diphenyl Ether Derivatives from the Marine-Derived Fungus Aspergillus candidus HM5-4

Ist Teil von

• Marine drugs, 2024-01, Vol.22 (1), p.13

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Two undescribed -terphenyl derivatives, asperterphenylcins A-B ( - ), and two undescribed diphenyl ether derivatives, asperdiphenylcins A-B ( - ), together with three previously described -terphenyl derivatives-4″-deoxyterprenin ( ), terphenyllin ( ), and 3″-hydroxyterphenyllin ( )-were obtained from the solid-rice culture of the marine-derived fungus HM5-4, which was isolated from sponges from the South China Sea. Their structures were elucidated by HRESIMS data and NMR spectroscopic analysis. Compound showed a strong inhibitory effect on , with an inhibition circle diameter of 31.67 ± 2.36 mm at a concentration of 10.0 µg/disc. Compounds and displayed cytotoxic activity against human chronic myeloid leukemia cells (K562), human liver cancer cells (BEL-7402), human gastric cancer cells (SGC-7901), human non-small cell lung cancer cells (A549) and human HeLa cervical cancer cells, with IC values ranging from 3.32 to 60.36 µM, respectively. Compounds , and showed potent inhibitory activity against -glucosidase, with IC values of 1.26 ± 0.19, 2.16 ± 0.44 and 13.22 ± 0.55 µM, respectively.