Details

Autor(en) / Beteiligte

• Juan, David
• Perner, Juliane
• Carrillo de Santa Pau, Enrique
• Marsili, Simone
• Ochoa, David
• Chung, Ho-Ryun
• Vingron, Martin
• Rico, Daniel
• Valencia, Alfonso

Titel

Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs

Ist Teil von

• Cell reports (Cambridge), 2016-02, Vol.14 (5), p.1246-1257

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs. [Display omitted] •Co-localization and literature analysis reveals global epigenomic communication network•5hmC is the most-influential hub in the epigenomic communication network of mESCs•Proteins editing and reading 5hmC signals co-evolve•5hmC communicates between different epigenomic processes through specific partners 5-hydroxymethylcytosine (5hmC) plays a key role in the epigenomic communication network of embryonic stem cells. Juan et al. build a communication network based in co-localization of epigenomic data and literature. The analysis of the network and its components reveals that proteins reading and editing 5hmC co-evolve and serve as links between diverse molecular processes.