Details

Autor(en) / Beteiligte

• Paganoni, Sabrina
• Alshikho, Mohamad J.
• Zürcher, Nicole R.
• Cernasov, Paul
• Babu, Suma
• Loggia, Marco L.
• Chan, James
• Chonde, Daniel B.
• Garcia, David Izquierdo
• Catana, Ciprian
• Mainero, Caterina
• Rosen, Bruce R.
• Cudkowicz, Merit E.
• Hooker, Jacob M.
• Atassi, Nazem

Titel

Imaging of glia activation in people with primary lateral sclerosis

Ist Teil von

• NeuroImage clinical, 2018-01, Vol.17, p.347-353

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Glia activation is thought to contribute to neuronal damage in several neurodegenerative diseases based on preclinical and human post-mortem studies, but its role in primary lateral sclerosis (PLS) is unknown. To localize and measure glia activation in people with PLS compared to healthy controls (HC). Ten participants with PLS and ten age-matched HCs underwent simultaneous magnetic resonance (MR) and proton emission tomography (PET). The radiotracer [11C]-PBR28 was used to obtain PET-based measures of 18kDa translocator protein (TSPO) expression, a marker of activated glial cells. MR techniques included a structural sequence to measure cortical thickness and diffusion tensor imaging (DTI) to assess white matter integrity. PET data showed increased [11C]-PBR28 uptake in anatomically-relevant motor regions which co-localized with areas of regional gray matter atrophy and decreased subcortical fractional anisotropy. This study supports a link between glia activation and neuronal degeneration in PLS, and suggests that these disease mechanisms can be measured in vivo in PLS. Future studies are needed to determine the longitudinal changes of these imaging measures and to clarify if MR-PET with [11C]-PBR28 can be used as a biomarker for drug development in the context of clinical trials for PLS. •Is there a relationship between glia activation, cortical atrophy, and subcortical white matter abnormalities in people with primary lateral sclerosis (PLS)?•In this cross-sectional in vivo multi-modal (MR-PET) neuroimaging study, we show evidence of glia activation in the motor regions in PLS patients compared to healthy controls. The increased glia activation co-localizes with areas of structural abnormalities including cortical atrophy and subcortical white matter changes.•MR-PET neuroimaging is a powerful technique to localize and quantify glia activation and structural abnormalities, and may represent a novel in vivo biomarker of disease mechanisms in PLS.