Details

Autor(en) / Beteiligte

• Sapienza, Lucas Gomes
• Maia, Maria Aparecida Conte
• Gomes, Maria José Leite
• Mattar, André
• Baiocchi, Glauco
• Calsavara, Vinicius Fernando

Titel

Randomized clinical trial of tissue equivalent bolus prescription in postmastectomy radiotherapy stratified by skin involvement status

Ist Teil von

• Clinical and translational radiation oncology, 2023-03, Vol.39, p.100570-100570, Article 100570

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• •Alternate-days bolus may be the most appropriated regimen to increase the absorbed dose in the superficial regions of the CW.•Due to the excess of G3 radiodermatitis events (70 %), the daily 5 mm-bolus should be avoided in PMRT for NIBC.•Toxicity-related treatment interruptions are avoided if the bolus is promptly discontinued when a G3 toxicity occurs.•The proposed rads-TI was able to capture the toxicity burden during the entire course of radiotherapy. To assess the impact and optimize the prescription of tissue-equivalent bolus in postmastectomy radiotherapy (PMRT), we compared the use of different bolus regimens tailored by skin involvement status. Patients with breast cancer who required PMRT were recruited (NCT01925651) and classified into two groups: standard-risk (SR, without skin involvement) and high-risk (HR, with skin involvement). SR was randomized between no bolus or 5 mm-bolus on alternate days and HR between 5 mm-bolus on alternate days or daily. Conventional fractionation (50.4 Gy; 1.8 Gy/daily) was used. Acute skin toxicity was evaluated blindly and the radiodermatitis-specific toxicity index [rads-TI] calculated. Subsequently, patients were followed up to assess oncologic outcomes, focusing on chest wall (CW) local control. Fifty-eight patients were enrolled (34 SR and 24 HR). Baseline characteristics were similar between arms within the same risk group. Overall, maximal radiodermatitis rates were 29.4 % (G2) and 15.7 % (G3). In the SR group, no difference existed in G2 radiodermatitis incidence between the subgroups (p = 0.70) and no G3 events occurred. In the HR group, incidences of G2 (100 % vs 44.5 %, p = 0.01) and G3 radiodermatitis (70 % vs 11.1 %, p = 0.02) were higher with daily bolus. After adjusting for confounders, the daily bolus had a higher incidence of G2 (p = 0.03), G3 radiodermatitis (p = 0.04), and worse rads-TI (p < 0.01). After a median follow-up of 6.2 years, the 5-year local control was 95.8 % (95 %CI: 88.2 %–100 %) in the SR and 91.7 % (95 %CI: 77.3 %–100 %) in the HR groups. Per risk group, there was no difference in local control between the SR (p = 0.90) or the HR bolus regimens (p = 0.70). Daily 5 mm bolus prescription significantly increased the overall toxicity burden. In this preliminary study, within the same risk group, no detriment in CW local control was detected with less intense bolus regimens (SR: no bolus; HR: alternate-days bolus). Additionally, the rads-TI was able to distinguish overall radiodermatitis burden.