Details

Autor(en) / Beteiligte

• Alcala, N
• Leblay, N
• Gabriel, A A G
• Mangiante, L
• Hervas, D
• Giffon, T
• Sertier, A S
• Ferrari, A
• Derks, J
• Ghantous, A
• Delhomme, T M
• Chabrier, A
• Cuenin, C
• Abedi-Ardekani, B
• Boland, A
• Olaso, R
• Meyer, V
• Altmuller, J
• Le Calvez-Kelm, F
• Durand, G
• Voegele, C
• Boyault, S
• Moonen, L
• Lemaitre, N
• Lorimier, P
• Toffart, A C
• Soltermann, A
• Clement, J H
• Saenger, J
• Field, J K
• Brevet, M
• Blanc-Fournier, C
• Galateau-Salle, F
• Le Stang, N
• Russell, P A
• Wright, G
• Sozzi, G
• Pastorino, U
• Lacomme, S
• Vignaud, J M
• Hofman, V
• Hofman, P
• Brustugun, O T
• Lund-Iversen, M
• Thomas de Montpreville, V
• Muscarella, L A
• Graziano, P
• Popper, H
• Stojsic, J
• Deleuze, J F
• Herceg, Z
• Viari, A
• Nuernberg, P
• Pelosi, G
• Dingemans, A M C
• Milione, M
• Roz, L
• Brcic, L
• Volante, M
• Papotti, M G
• Caux, C
• Sandoval, J
• Hernandez-Vargas, H
• Brambilla, E
• Speel, E J M
• Girard, N
• Lantuejoul, S
• McKay, J D
• Foll, M
• Fernandez-Cuesta, L

Titel

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

Ist Teil von

• Nature communications, 2019-08, Vol.10 (1), p.3407-21, Article 3407

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms.