Details

Autor(en) / Beteiligte

• Temel Yuksel, Ilkbal
• Mathyk, Begum Aydogan
• Aslan Cetin, Berna
• Turhan, Ugur
• Okumus, Zihniye Gonca
• Yetkin Yildirim, Gonca
• Acar, Deniz Kanber

Titel

Maternal levels of growth differentiation factor-15 in patients with preeclampsia

Ist Teil von

• Hypertension in pregnancy, 2018-10, Vol.37 (4), p.192-196

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits. Results: The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009). Conclusion: Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.