Details

Autor(en) / Beteiligte

• Nakajima, Ken-ichiro
• Cui, Zhenzhong
• Li, Chia
• Meister, Jaroslawna
• Cui, Yinghong
• Fu, Ou
• Smith, Adam S.
• Jain, Shalini
• Lowell, Bradford B.
• Krashes, Michael J.
• Wess, Jürgen

Titel

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

Ist Teil von

• Nature communications, 2016-01, Vol.7 (1), p.10268-10268, Article 10268

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2016

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling properties, including G s -linked GPCRs. At present, the potential role of G s -coupled GPCRs in regulating the activity of AgRP neurons remains unknown. Here we show that the activation of G s -coupled receptors expressed by AgRP neurons leads to a robust and sustained increase in food intake. We also provide detailed mechanistic data linking the stimulation of this class of receptors to the observed feeding phenotype. Moreover, we show that this pathway is clearly distinct from other GPCR signalling cascades that are operative in AgRP neurons. Our data suggest that drugs able to inhibit this signalling pathway may become useful for the treatment of obesity. Hypothalamic Agouti-related peptide (AgRP) neurons play a key role in regulating food intake. Here, the authors report a novel pathway in which activation of Gs-coupled receptors on AgRP neurons leads to robust, sustained increase in food intake.