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Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial
Ist Teil von
Microorganisms (Basel), 2021-04, Vol.9 (4), p.854
Ort / Verlag
Switzerland: MDPI AG
Erscheinungsjahr
2021
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strategies for recovery from AD lesions are continually being explored. In this article, we describe the gut microbiome changes achieved in a recently published clinical trial with the probiotic formulation
subsp.
CECT 8145,
CECT 7347, and
CECT 9104 (formerly
CECT 9104), showing a significant improvement in SCORAD (scoring atopic dermatitis) index in children (4-17 years) with AD (Clinicaltrials.gov identifier: NCT02585986). The present gut microbiome post hoc study showed no significant changes in diversity (Shannon and Simpson indexes) after probiotic consumption. In the probiotic group, genera
, and
significantly increased their levels while
decreased, compared to the placebo group.
showed the highest presence and significant positive correlation with AD severity (SCORAD index), whereas
and
were inversely correlated. The results suggest that the consumption of the probiotic formulation here assayed modulates the gut microbiome with significant changes in genera
and
. In turn, the improvement in SCORAD correlates with a decrease in
and an increase in
, among others.