Details

Autor(en) / Beteiligte

• Chiba, Shiho
• Ikushima, Hiroaki
• Ueki, Hiroshi
• Yanai, Hideyuki
• Kimura, Yoshitaka
• Hangai, Sho
• Nishio, Junko
• Negishi, Hideo
• Tamura, Tomohiko
• Saijo, Shinobu
• Iwakura, Yoichiro
• Taniguchi, Tadatsugu

Titel

Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

Ist Teil von

• eLife, 2014-08, Vol.3, p.e04177-e04177

Ort / Verlag

England: eLife Sciences Publications Ltd

Erscheinungsjahr

2014

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications.