Details

Autor(en) / Beteiligte

• Huang, Enyu
• Peng, Na
• Xiao, Fan
• Hu, Dajun
• Wang, Xiaohui
• Lu, Liwei

Titel

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Ist Teil von

• International journal of molecular sciences, 2020-07, Vol.21 (15), p.5203

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.