Details

Autor(en) / Beteiligte

• Lavell, A.H. Ayesha
• Sikkens, Jonne J.
• Edridge, Arthur W.D.
• van der Straten, Karlijn
• Sechan, Ferdyansyah
• Oomen, Melissa
• Buis, David T.P.
• Schinkel, Michiel
• Burger, Judith A.
• Poniman, Meliawati
• van Rijswijk, Jacqueline
• de Jong, Menno D.
• de Bree, Godelieve J.
• Peters, Edgar J.G.
• Smulders, Yvo M.
• Sanders, Rogier W.
• van Gils, Marit J.
• van der Hoek, Lia
• Bomers, Marije K.

Titel

Recent infection with HCoV-OC43 may be associated with protection against SARS-CoV-2 infection

Ist Teil von

• iScience, 2022-10, Vol.25 (10), p.105105-105105, Article 105105

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Antibodies against seasonal human coronaviruses (HCoVs) are known to cross-react with SARS-CoV-2, but data on cross-protective effects of prior HCoV infections are conflicting. In a prospective cohort of healthcare workers (HCWs), we studied the association between seasonal HCoV (OC43, HKU1, 229E and NL63) nucleocapsid protein IgG and SARS-CoV-2 infection during the first pandemic wave in the Netherlands (March 2020 – June 2020), by 4-weekly serum sampling. HCW with HCoV-OC43 antibody levels in the highest quartile, were less likely to become SARS-CoV-2 seropositive when compared with those with lower levels (6/32, 18.8%, versus 42/97, 43.3%, respectively: p = 0.019; HR 0.37, 95% CI 0.16–0.88). We found no significant association with HCoV-OC43 spike protein IgG, or with antibodies against other HCoVs. Our results indicate that the high levels of HCoV-OC43-nucleocapsid antibodies, as an indicator of a recent infection, are associated with protection against SARS-CoV-2 infection; this supports and informs efforts to develop pancoronavirus vaccines. [Display omitted] •High OC43 anti-nucleocapsid IgG suggests a recent infection with human coronavirus OC43•Persons with high OC43 anti-nucleocapsid IgG are less likely to contract SARS-CoV-2 Molecular physiology; Immunology; Virology