Details

Autor(en) / Beteiligte

• Ezzyat, Youssef
• Wanda, Paul A
• Levy, Deborah F
• Kadel, Allison
• Aka, Ada
• Pedisich, Isaac
• Sperling, Michael R
• Sharan, Ashwini D
• Lega, Bradley C
• Burks, Alexis
• Gross, Robert E
• Inman, Cory S
• Jobst, Barbara C
• Gorenstein, Mark A
• Davis, Kathryn A
• Worrell, Gregory A
• Kucewicz, Michal T
• Stein, Joel M
• Gorniak, Richard
• Das, Sandhitsu R
• Rizzuto, Daniel S
• Kahana, Michael J

Titel

Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Ist Teil von

• Nature communications, 2018-02, Vol.9 (1), p.365-8, Article 365

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.