Details

Autor(en) / Beteiligte

• Kim, Doo Hyun
• Park, Eun-Sook
• Lee, Ah Ram
• Park, Soree
• Park, Yong Kwang
• Ahn, Sung Hyun
• Kang, Hong Seok
• Won, Ju Hee
• Ha, Yea Na
• Jae, ByeongJune
• Kim, Dong-Sik
• Chung, Woo-Chang
• Song, Moon Jung
• Kim, Kee-Hwan
• Park, Seung Hwa
• Kim, Soo-Hyun
• Kim, Kyun-Hwan

Titel

Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus

Ist Teil von

• Nature communications, 2018-08, Vol.9 (1), p.3284-15, Article 3284

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription and replication. The gamma isoform of IL-32 (IL-32γ) inhibits viral enhancer activities by downregulating liver-enriched transcription factors. Our data are validated in both an in vivo HBV mouse model and primary human hepatocytes. This study thus suggests that IL-32γ functions as intracellular effector in hepatocytes for suppressing HBV replication to implicate a possible mechanism of non-cytopathic viral clearance.