Details

Autor(en) / Beteiligte

• Zengin, Gokhan
• Menghini, Luigi
• Di Sotto, Antonella
• Mancinelli, Romina
• Sisto, Francesca
• Carradori, Simone
• Cesa, Stefania
• Fraschetti, Caterina
• Filippi, Antonello
• Angiolella, Letizia
• Locatelli, Marcello
• Mannina, Luisa
• Ingallina, Cinzia
• Puca, Valentina
• D'Antonio, Marianna
• Grande, Rossella

Titel

Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

Ist Teil von

• Molecules (Basel, Switzerland), 2018-12, Vol.23 (12), p.3266

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Due to renewed interest in the cultivation and production of Italian L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, α-amylase, α-glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains ( , , , and spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.