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Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine
Ist Teil von
Journal of Pharmacological Sciences, 2003, Vol.92(2), pp.149-152
Ort / Verlag
Japan: The Japanese Pharmacological Society
Erscheinungsjahr
2003
Quelle
MEDLINE
Beschreibungen/Notizen
We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.