Details

Autor(en) / Beteiligte

• Araújo-Pereira, Mariana
• Nogueira, Betânia M.F.
• Spener-Gomes, Renata
• Carvalho, Anna C.C.
• Sant’Anna, Flávia Marinho
• Figueiredo, Marina C.
• Turner, Megan M.
• Kritski, Afrânio L.
• Cordeiro-Santos, Marcelo
• Rolla, Valeria C.
• Sterling, Timothy R.
• Andrade, Bruno B.
• Andrade, Alice M.S.
• Nascimento, Vanessa
• Cubillos-Angulo, Juan Manuel
• Malta-Santos, Hayna
• Rebouças-Silva, Jéssica
• Santos, Saulo R.N.
• Ramos, André
• Brito, Pedro
• Schmaltz, Carolina A.S.
• Costa, Alysson G.
• Sousa Garcia, Leandro
• de Sousa Carvalho, Brenda K.
• de Loiola, Bruna P.
• Gomes-Silva, Adriano
• Ignácio, Francine P.
• Lourenço, Maria C.
• Silva, Elisangela C.
• Mello, Mayla
• Souza, Alexandra B.
• Barreto-Duarte, Beatriz
• Rocha, Michael S.
• Benjamin, Aline
• Moreira, Adriana S.R.
• de Oliveira, Jamile G.
• Cavalcante, Solange
• Durovni, Betina
• Lapa-e-Silva, José R.

Titel

Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study

Ist Teil von

• Journal of infection and public health, 2023-06, Vol.16 (6), p.974-980

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. Patients ≥ 18 years old with culture-confirmed drug-susceptible pulmonary TB enrolled between 2015 and 2019 in a multi-center Brazilian cohort were followed for up to 24 months and classified according to anemia severity (mild, moderate, and severe), based on hemoglobin levels. A multinomial logistic regression model was employed to assess whether anemia was associated with unfavorable outcome (death, failure, loss to follow-up, regimen modification or relapse), compared to treatment success (cure or treatment completion). Among 786 participants who met inclusion criteria, 441 (56 %) were anemic at baseline. Patients with moderate/severe anemia were more HIV-seropositive, as well as more symptomatic and had higher frequencies of unfavorable outcomes compared to the other groups. Moderate/severe anemia (adjusted OR [aOR]: 7.80, 95 %CI:1.34–45.4, p = 0.022) was associated with death independent of sex, age, BMI, HIV and glycemic status. Moderate/severe anemia prior to ATT was a significant risk factor for death. Such patients should be closely monitored given the high risk of unfavorable ATT outcomes.