Details

Autor(en) / Beteiligte

• Zhao, Guo-ping
• Cheng, Wei-long
• Zhang, Zhi-hui
• Li, Yi-xuan
• Li, Ying-qiu
• Yang, Fang-wei
• Wang, Yan-bo

Titel

The use of amino acids and their derivates to mitigate against pesticide-induced toxicity

Ist Teil von

• Ecotoxicology and environmental safety, 2024-05, Vol.276, p.116340-116340, Article 116340

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Exposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances in amino acid levels within the organism. One potentially effective strategy to mitigate pesticide toxicity involves dietary intervention by supplementing exogenous amino acids and their derivates to augment the body’s antioxidant capacity and mitigate pesticide-induced oxidative harm, whose mechanism including bolstering glutathione synthesis, regulating arginine-NO metabolism, mitochondria-related oxidative stress, and the open of ion channels, as well as enhancing intestinal microecology. Enhancing glutathione synthesis through supplementation of substrates N-acetylcysteine and glycine is regarded as a potent mechanism to achieve this. Selection of appropriate amino acids or their derivates for supplementation, and determining an appropriate dosage, are of the utmost importance for effective mitigation of pesticide-induced oxidative harm. More experimentation is required that involves large population samples to validate the efficacy of dietary intervention strategies, as well as to determine the effects of amino acids and their derivates on long-term and low-dose pesticide exposure. This review provides insights to guide future research aimed at preventing and alleviating pesticide toxicity through dietary intervention of amino acids and their derivates. •Amino acids and their derivates could mitigate toxic effects induced by pesticides.•Pesticide triggers organ damage via pathways associated with oxidative stress.•Several underlying mechanisms are involved for the amino acid-derived intervention.•More studies are needed to elucidate optimal intervention dose and action patterns.