Details

Autor(en) / Beteiligte

• Devassy, Diana
• Harshad, Sujata
• Devarbhai, Harshad

Titel

Pompholyx-like eruptions induced by penicillamine in a patient with wilson's disease

Ist Teil von

• Indian journal of dermatology, 2019-07, Vol.64 (4), p.321-323

Ort / Verlag

India: Wolters Kluwer India Pvt. Ltd

Erscheinungsjahr

2019

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Wilson's disease is an inherited disorder of copper metabolism that results in excessive accumulation of copper in various organs, with liver being the primary site of involvement. D-penicillamine (DPA) as a chelating agent forms the mainstay of therapy; however, it can cause a myriad of adverse effects on long-term use. The major adverse effects reported with DPA include disorders of collagen synthesis, such as pseudoxanthoma elasticum-like lesions, autoimmune blistering diseases, and urticarial lesions. Here, we report a young girl who developed extensive pompholyx-like blisters within a few months of starting DPA which on histopathology showed a spongiotic reaction. The lesions improved on stopping DPA and initiation of oral steroids.