Details

Autor(en) / Beteiligte

• Lyngbakken, Magnus Nakrem
• Berdal, Jan-Erik
• Eskesen, Arne
• Kvale, Dag
• Olsen, Inge Christoffer
• Rueegg, Corina Silvia
• Rangberg, Anbjørg
• Jonassen, Christine Monceyron
• Omland, Torbjørn
• Røsjø, Helge
• Dalgard, Olav

Titel

A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics

Ist Teil von

• Nature communications, 2020-10, Vol.11 (1), p.5284-5284, Article 5284

Ort / Verlag

London: Nature Publishing Group

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Here, we randomized 53 patients hospitalized with coronavirus disease 2019 (COVID-19) to hydroxychloroquine therapy (at a dose of 400 mg twice daily for seven days) in addition to standard care or standard care alone (ClinicalTrials.gov Identifier, NCT04316377). All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients 18 years of age or older were eligible for study inclusion if they had moderately severe COVID-19 at admission. Treatment with hydroxychloroquine did not result in a significantly greater rate of decline in SARS-CoV-2 oropharyngeal viral load compared to standard care alone during the first five days. Our results suggest no important antiviral effect of hydroxychloroquine in humans infected with SARS-CoV-2.