Details

Autor(en) / Beteiligte

• Hindley, Andrew
• Catherwood, Mark Alexander
• McMullin, Mary Frances
• Mills, Ken I.

Titel

Significance of NPM1 Gene Mutations in AML

Ist Teil von

• International journal of molecular sciences, 2021-09, Vol.22 (18), p.10040

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2021

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of NPM1 mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting NPM1 mutated AML are considered.