Details

Autor(en) / Beteiligte

• Kim, Mun-Ock
• Lee, Su Ui
• Yuk, Heung Joo
• Jang, Hyun-Jae
• Lee, Jae-Won
• Kwon, Eun-Bin
• Paik, Jin-Hyub
• Choi, SangHo
• Nizar, Adek
• The Bach, Tran
• Sydara, Kongmany
• Jin, Hang
• Woo, So-Yeun
• Oh, Sei-Ryang
• Ryu, Hyung Won

Titel

Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species

Ist Teil von

• Journal of functional foods, 2020-01, Vol.64, p.103684, Article 103684

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2020

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• [Display omitted] •Lagerstroemia species were successfully discriminated using PLS-DA analysis data.•Inhibition of glucose uptake was found depending on the corosolic acid content.•L. ovalifolia and L. speciosa showed better antidiabetic activity than others.•Metabolomics approach can distinguish with similar bioactivity based on components. Rational and efficient approaches to research and development are becoming more popular for increasing value enhancement in bioactive materials. In this study, metabolite profiles of 17 different Lagerstroemia species from different countries were performed using UPLC-QTof-MS combined with chemometric tools to identify potential metabolite predictors of antidiabetic activity. PLS-DA of the Lagerstroemia samples indicated two large, distinct clusters in the score plot. On the loading scatter plot, significant changes in metabolites of antidiabetic candidates were found between species, and two flavonol glycosides and corosolic acid were evaluated as key markers among the 25 analyzed metabolites. Based on the screening results, samples high in two triterpenic acids (corosolic acid and asiatic acid) showed a tendency to inhibit glucose uptake, which could have contributed to the correlation of active and inactive extracts. Therefore, these comprehensive results support our biochemometric models and contribute to the rational and efficient studies of pharmacologically active metabolites.