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Orphan SelD proteins and selenium-dependent molybdenum hydroxylases
Ist Teil von
Biology direct, 2008-02, Vol.3 (1), p.4-4
Ort / Verlag
England: BioMed Central Ltd
Erscheinungsjahr
2008
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Bacterial and Archaeal cells use selenium structurally in selenouridine-modified tRNAs, in proteins translated with selenocysteine, and in the selenium-dependent molybdenum hydroxylases (SDMH). The first two uses both require the selenophosphate synthetase gene, selD. Examining over 500 complete prokaryotic genomes finds selD in exactly two species lacking both the selenocysteine and selenouridine systems, Enterococcus faecalis and Haloarcula marismortui. Surrounding these orphan selD genes, forming bidirectional best hits between species, and detectable by Partial Phylogenetic Profiling vs. selD, are several candidate molybdenum hydroxylase subunits and accessory proteins. We propose that certain accessory proteins, and orphan selD itself, are markers through which new selenium-dependent molybdenum hydroxylases can be found.