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Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity
Ist Teil von
Frontiers in nutrition (Lausanne), 2021-06, Vol.8, p.689419-689419
Ort / Verlag
Frontiers Media S.A
Erscheinungsjahr
2021
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Background:
COVID-19 pandemic has proved to be an unrelenting health threat for more than a year now. The emerging amount of data indicates that vitamin D, zinc and selenium could be important for clinical presentation of COVID-19. Here, we investigated association of genetic variants related to the altered level and bioavailability of vitamin D, zinc and selenium with clinical severity of COVID-19.
Methods:
We analyzed variants in genes significant for the status of vitamin D (
DHCR7
/
NADSYN1
rs12785878, GC rs2282679,
CYP2R1
rs10741657, and
VDR
rs2228570), zinc (
PPCDC
rs2120019) and selenium (
DMGDH
rs17823744) in 120 Serbian adult and pediatric COVID-19 patients using allelic discrimination. Furthermore, we carried out comparative population genetic analysis among European and other worldwide populations to investigate variation in allelic frequencies of selected variants.
Results:
Study showed that
DHCR7/NADSYN
rs12785878 and
CYP2R1
rs10741657 variants were associated with severe COVID-19 in adults (
p
= 0.03,
p
= 0.017, respectively); carriers of
DHCR7/NADSYN
TG+GG and
CYP2R1
GG genotypes had 0.21 and 5.9 the odds for developing severe disease, OR 0.21 (0.05–0.9) and OR 5.9 (1.4–25.2), respectively. There were no associations between selected genetic variants and disease severity in pediatric patients. Comparative population genetic analysis revealed that Serbian population had the lowest frequency of
CYP2R1
rs10741657 G allele compared to other non-Finish Europeans (0.58 compared to 0.69 and 0.66 in Spanish and Italian population, respectively), suggesting that other populations should also investigate the relationship of
CYP2R1
variant and the COVID-19 disease course.
Conclusion:
The results of the study indicated that vitamin D related genetic variants were implicated in severe COVID-19 in adults. This could direct prevention strategies based on population specific nutrigenetic profiles.