Emerging infectious diseases, 2019-03, Vol.25 (3), p.577-580
2019
Details
- Autor(en) / Beteiligte
- Titel
- In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR 120 ) in Aspergillus fumigatus cyp51A, Denmark
- Ist Teil von
- Emerging infectious diseases, 2019-03, Vol.25 (3), p.577-580
- Ort / Verlag
- United States: U.S. National Center for Infectious Diseases
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1080-6040eISSN: 1080-6059DOI: 10.3201/eid2503.180297Titel-ID: cdi_doaj_primary_oai_doaj_org_article_d183ec7c70df4d2d9e2afabf6c4a9ca2
- Format
- –
- Schlagworte
- Antifungal agents, Aspergillosis, Aspergillosis - diagnosis, Aspergillosis - drug therapy, Aspergillosis - epidemiology, Aspergillosis - microbiology, Aspergillus, Aspergillus fumigatus - drug effects, Aspergillus fumigatus - genetics, azole resistance, Azoles, Azoles (Class of compounds), Azoles - pharmacology, Azoles - therapeutic use, Care and treatment, Complications and side effects, Cytochrome P-450 Enzyme System - genetics, Death, Denmark, Denmark - epidemiology, Dispatch, DNA sequencing, Drug resistance, Drug Resistance, Fungal, fungal infections, Fungal Proteins - genetics, Fungicides, Genomes, Genomics, Humans, in, in vivo selection, In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR, Male, Middle Aged, Mutation, Mycoses, Phylogeny, Posaconazole, Promoter Regions, Genetic, promoter TR120, Selection, Genetic, Steroids (Organic compounds), tandem repeat resistance mechanism, Tandem Repeat Sequences, Tomography, X-Ray Computed, whole-genome sequencing