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Antimicrobial peptides and proteins of the horse--insights into a well-armed organism
Ist Teil von
Veterinary research (Paris), 2011-09, Vol.42 (1), p.98-98
Ort / Verlag
England: BioMed Central Ltd
Erscheinungsjahr
2011
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Antimicrobial peptides play a pivotal role as key effectors of the innate immune system in plants and animals and act as endogenous antibiotics. The molecules exhibit an antimicrobial activity against bacteria, viruses, and eukaryotic pathogens with different specificities and potencies depending on the structure and amino-acid composition of the peptides. Several antimicrobial peptides were comprehensively investigated in the last three decades and some molecules with remarkable antimicrobial properties have reached the third phase of clinical studies. Next to the peptides themselves, numerous organisms were examined and analyzed regarding their repertoire of antimicrobial peptides revealing a huge number of candidates with potencies and properties for future medical applications. One of these organisms is the horse, which possesses numerous peptides that are interesting candidates for therapeutical applications in veterinary medicine. Here we summarize investigations and knowledge on equine antimicrobial peptides, point to interesting candidates, and discuss prospects for therapeutical applications.