Details

Autor(en) / Beteiligte

• Blau, Lorena
• Menegon, Renato Farina
• Ferreira, Elizabeth Igne
• Ferreira, Antonio Gilberto
• Boffo, Elisangela Fabiana
• Tavares, Leila Aley
• Heleno, Vladimir Constantino Gomes
• Chung, Man-Chin

Titel

Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches

Ist Teil von

• Molecules (Basel, Switzerland), 2008-04, Vol.13 (4), p.841-854

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4''-nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]- 5-dioxide (7) are also described, together with their total (1)H- and (13)C-NMR assignments.