Details

Autor(en) / Beteiligte

• Wilson, Duncan
• Ambler, Gareth
• Shakeshaft, Clare
• Banerjee, Gargi
• Charidimou, Andreas
• Seiffge, David
• White, Mark
• Cohen, Hannah
• Yousry, Tarek
• Rustam, Al-Shahi Salman
• Lip, Gregory Y H
• Muir, Keith
• Brown, Martin M
• Jäger, H R
• Werring, David J
• Harkness, Kirsty
• Shaw, Louise
• Sword, Jane
• Nor, Azlisham Mohd
• Sharma, Pankaj
• Veltkamp, Roland
• Kelly, Deborah
• Harrington, Frances
• Randall, Marc
• Smith, Matthew
• Mahawish, Karim
• Elmarim, Abduelbaset
• Esisi, Bernard
• Cullen, Claire
• Nallasivam, Arumug
• Price, Christopher
• Barry, Adrian
• Roffe, Christine
• Coyle, John
• Hassan, Ahamad
• Lovelock, Caroline
• Birns, Jonathan
• Cohen, David
• Sekaran, L
• Parry-Jones, Adrian
• Parry, Anthea
• Hargroves, David
• Proschel, Harald
• Datta, Prabel
• Darawil, Khaled
• Manoj, Aravindakshan
• Burn, Mathew
• Patterson, Chris
• Giallombardo, Elio
• Smyth, Nigel
• Mansoor, Syed
• Anwar, Ijaz
• Marsh, Rachel
• Ispoglou, Sissi
• Chadha, Dinesh
• Prabhakaran, Mathuri
• Meenakishundaram, Sanjeevikumar
• O’Connell, Janice
• Scott, Jon
• Krishnamurthy, Vinodh
• Aghoram, Prasanna
• Mccormick, Michael
• Paul O’Mahony, Nikola Sprigg
• Cooper, Martin
• Choy, Lillian
• Wilkinson, Peter
• Leach, Simon
• Caine, Sarah
• Burger, Ilse
• Gunathilagan, Gunaratam
• Guyler, Paul
• Emsley, Hedley
• Davis, Michelle
• Manawadu, Dulka
• Pasco, Kath
• Mamun, Maam
• Luder, Robert
• Sajid, Mahmud
• Okwera, James
• Staals, Julie
• Warburton, Elizabeth
• Saastamoinen, Kari
• England, Timothy
• Putterill, Janet
• Flossman, Enrico
• Power, Michael
• Dani, Krishna
• Mangion, David
• Suman, Appu
• Corrigan, John
• Lawrence, Enas
• Vahidassr, Djamil

Titel

Potential missed opportunities to prevent ischaemic stroke: prospective multicentre cohort study of atrial fibrillation-associated ischaemic stroke and TIA

Ist Teil von

• BMJ open, 2019-07, Vol.9 (7), p.e028387

Ort / Verlag

England: British Medical Journal Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• ObjectiveWe report on: (1) the proportion of patients with known atrial fibrillation (AF); and (2) demographic, clinical or radiological differences between patients with known AF (and not treated) and patients with newly diagnosed AF, in a cohort of patients who presented with ischaemic stroke or transient ischaemic attack (TIA) not previously treated with anticoagulation.DesignWe reviewed cross-sectional baseline demographic and clinical data from a prospective observational cohort study, (CROMIS-2).SettingPatients were recruited from 79 hospital stroke centres throughout the UK and one centre in the Netherlands.ParticipantsPatients were eligible if they were adults who presented with ischaemic stroke or TIA and AF and had not been previously treated with oral anticoagulation.Main outcome measuresProportion of patients with known AF before index ischaemic stroke or TIA from a cohort of patients who have not been previously treated with oral anticoagulation. Secondary analysis includes the comparison of CHA2DS2-VASc and HAS-BLED scores and other demographics and risk factors between those with newly diagnosed AF and those with previously known AF.ResultsOf 1470 patients included in the analysis (mean age 76 years (SD 10)), 622 (42%) were female; 999 (68%) patients had newly diagnosed AF and 471 (32%) patients had known AF. Of the 471 patients with known AF, 68% had a strong indication for anticoagulation and 89% should have been considered for anticoagulation based upon CHA2DS2-VASc score. Patients with known AF were more likely to have a prior history of dementia (4% vs 2%, p=0.02) and had higher HAS-BLED scores (median 3 vs 2). CHA2DS2-VASc, other risk factors and demographics were similar.ConclusionsAbout 1/3 of patients who present with stroke and have AF who have not been treated with oral anticoagulation have previously known AF. Of these patients, at least 68% were not adequately treated with oral anticoagulation.Trial registration number NCT02513316.