Details

Autor(en) / Beteiligte

• Oben, Bénedith
• Froyen, Guy
• Maclachlan, Kylee H
• Leongamornlert, Daniel
• Abascal, Federico
• Zheng-Lin, Binbin
• Yellapantula, Venkata
• Derkach, Andriy
• Geerdens, Ellen
• Diamond, Benjamin T
• Arijs, Ingrid
• Maes, Brigitte
• Vanhees, Kimberly
• Hultcrantz, Malin
• Manasanch, Elisabet E
• Kazandjian, Dickran
• Lesokhin, Alexander
• Dogan, Ahmet
• Zhang, Yanming
• Mikulasova, Aneta
• Walker, Brian
• Morgan, Gareth
• Campbell, Peter J
• Landgren, Ola
• Rummens, Jean-Luc
• Bolli, Niccolò
• Maura, Francesco

Titel

Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Ist Teil von

• Nature communications, 2021-03, Vol.12 (1), p.1861-1861, Article 1861

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate the whole genome sequence (WGS) profile of 18 MGUS and compare them with those from 14 SMMs and 80 MMs. We show that cases with a non-progressing, clinically stable myeloma precursor condition (n = 15) are characterized by later initiation in the patient's life and by the absence of myeloma defining genomic events including: chromothripsis, templated insertions, mutations in driver genes, aneuploidy, and canonical APOBEC mutational activity. This data provides evidence that WGS can be used to recognize two biologically and clinically distinct myeloma precursor entities that are either progressive or stable.