Details

Autor(en) / Beteiligte

• Razazi, Keyvan
• Boissier, Florence
• Neuville, Mathilde
• Jochmans, Sébastien
• Tchir, Martial
• May, Faten
• de Prost, Nicolas
• Brun-Buisson, Christian
• Carteaux, Guillaume
• Mekontso Dessap, Armand

Titel

Pleural effusion during weaning from mechanical ventilation: a prospective observational multicenter study

Ist Teil von

• Annals of intensive care, 2018-11, Vol.8 (1), p.103-10, Article 103

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Springer Nature - Complete Springer Journals

Beschreibungen/Notizen

• Background Pleural effusion is common during invasive mechanical ventilation, but its role during weaning is unclear. We aimed at assessing the prevalence and risk factors for pleural effusion at initiation of weaning. We also assessed its impact on weaning outcomes and its evolution in patients with difficult weaning. Methods We performed a prospective multicenter study in five intensive care units in France. Two hundred and forty-nine patients were explored using ultrasonography. Presence of moderate-to-large pleural effusion (defined as a maximal interpleural distance ≥ 15 mm) was assessed at weaning start and during difficult weaning. Results Seventy-three (29%) patients failed weaning, including 46 (18%) who failed the first spontaneous breathing trial (SBT) and 39 (16%) who failed extubation. Moderate-to-large pleural effusion was detected in 81 (33%) patients at weaning start. Moderate-to-large pleural effusion was associated with more failures of the first SBT [27 (33%) vs. 19 (11%), p  < 0.001], more weaning failures [37 (47%) vs. 36 (22%), p  < 0.001], less ventilator-free days at day 28 [21 (5–24) vs. 23 (16–26), p  = 0.01], and a higher mortality at day 28 [14 (17%) vs. 14 (8%), p  = 0.04]. The association of pleural effusion with weaning failure persisted in multivariable analysis and sensitivity analyses. Short-term (48 h) fluid balance change was not associated with the evolution of interpleural distance in patients with difficult weaning. Conclusions In this multicenter observational study, pleural effusion was frequent during the weaning process and was associated with worse weaning outcomes.