International journal of molecular sciences, 2020-03, Vol.21 (6), p.2091
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
- Ist Teil von
- International journal of molecular sciences, 2020-03, Vol.21 (6), p.2091
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2020
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1422-0067, 1661-6596eISSN: 1422-0067DOI: 10.3390/ijms21062091Titel-ID: cdi_doaj_primary_oai_doaj_org_article_ce54a0fad7c04960b66b4e5a051ec203
- Format
- –
- Schlagworte
- Binding sites, cell-to-cell transmission, Chronic infection, endocytosis, fusion, Genomes, Glycoproteins, Heparan sulfate, Hepatitis, Hepatitis C, hepatitis c virus, hepatocyte, Hepatocytes, Human health and pathology, Hépatology and Gastroenterology, Infections, Life Sciences, Lipids, Lipoproteins, Liver, Liver diseases, Medical research, Microbiology and Parasitology, Microscopy, Molecular modelling, Proteins, Researchers, Review, Tropism, Vaccines, viral entry, Viral infections, Virology, Viruses