Details

Autor(en) / Beteiligte

• Fong, Warren
• Woon, Ting Hui
• Chew, Li-Ching
• Low, Andrea
• Law, Annie
• Poh, Yih Jia
• Yeo, Siaw Ing
• Leung, Ying Ying
• Ma, Margaret
• Santosa, Amelia
• Kong, Kok Ooi
• Xu, Chuanhui
• Teng, Gim Gee
• Mak, Anselm
• Tay, Sen Hee
• Chuah, Tyng Yu
• Roslan, Nur Emillia
• Angkodjojo, Stanley
• Phang, Kee Fong
• Sriranganathan, Melonie
• Tan, Teck Choon
• Cheung, Peter
• Lahiri, Manjari

Titel

Prevalence and factors associated with flares following COVID-19 mRNA vaccination in patients with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: a national cohort study

Ist Teil von

• Advances in rheumatology (London, England), 2023-08, Vol.63 (1), p.38-38

Ort / Verlag

England: BioMed Central

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To determine prevalence and factors associated with flares post Coronavirus disease 2019 (COVID-19) mRNA vaccination in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA). A retrospective multi-centre study was conducted (January 2021 to February 2022). Data were collected during index visit, defined as first post-vaccine visit in which the patient had a physician-defined flare, or if at least 3 months had elapsed since first vaccine dose, whichever came first. Factors associated with flares were identified using mixed effects Cox regression and expressed as hazard ratio (HR) and 95% confidence interval (CI). Total of 2377 patients were included (1563 RA, 415 PsA and 399 SpA). Among patients with RA, PsA and SpA, 21.3%, 24.1% and 21.8% experienced a flare respectively. Of those who experienced a flare, only 10.2%, 11.0% and 14.9% were severe in patients with RA, PsA and SpA respectively. Patients with low or moderate/high disease were more likely to flare compared to those in remission in patients with RA only (HR: 1.68, 95% CI 1.22-2.31; HR: 2.28, 95% CI 1.50-3.48, respectively). Receiving the Moderna vaccine was associated with a higher HR of flare compared to the Pfizer vaccine in patients with PsA only (HR: 2.21, 95% CI 1.20-4.08). Patients who had two vaccine doses were found to be less likely to flare (HR: 0.08, 95% CI 0.06-0.10). HRs of flares were not significantly different among RA, PsA and SpA. About one-fifth of patients experienced a disease flare post COVID-19 mRNA vaccination, but most flares were non-severe. Patients with active disease prior to vaccination should be monitored closely for disease flares, especially in patients with RA.