Molecules (Basel, Switzerland), 2022-08, Vol.27 (15), p.4975
2022
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Details
- Autor(en) / Beteiligte
- Titel
- The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2
- Ist Teil von
- Molecules (Basel, Switzerland), 2022-08, Vol.27 (15), p.4975
- Ort / Verlag
- Basel: MDPI AG
- Erscheinungsjahr
- 2022
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules27154975Titel-ID: cdi_doaj_primary_oai_doaj_org_article_ccf7c0d76b51471eb97df4d970b00559
- Format
- –
- Schlagworte
- Animal models, Antiviral agents, antiviral drugs, Aprotinin, Bacterial pneumonia, Body weight, Body weight loss, Coronaviruses, COVID-19, Dosage and administration, Drug therapy, Drug therapy, Combination, Drugs, Infections, Influenza, Mortality, Pneumonia, SARS-CoV-2, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Survival, Testing, Viruses, Weight loss