Details

Autor(en) / Beteiligte

• Girard, Bethany
• Baum-Jones, Elisabeth
• Best, Rebecca L
• Campbell, Thomas W
• Coupart, Jack
• Dangerfield, Kyla
• Dhal, Abhilash
• Jhatro, Michael
• Martinez, Brian
• Reifert, Jack
• Shon, John
• Zhang, Minlu
• Waitz, Rebecca
• Chalkias, Spyros
• Edwards, Darin K
• Maglinao, Maha
• Paris, Robert
• Pajon, Rolando

Titel

Profiling antibody epitopes induced by mRNA-1273 vaccination and boosters

Ist Teil von

• Frontiers in immunology, 2024-03, Vol.15, p.1285278-1285278

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Characterizing the antibody epitope profiles of messenger RNA (mRNA)-based vaccines against SARS-CoV-2 can aid in elucidating the mechanisms underlying the antibody-mediated immune responses elicited by these vaccines. This study investigated the distinct antibody epitopes toward the SARS-CoV-2 spike (S) protein targeted after a two-dose primary series of mRNA-1273 followed by a booster dose of mRNA-1273 or a variant-updated vaccine among serum samples from clinical trial adult participants. Multiple S-specific epitopes were targeted after primary vaccination; while signal decreased over time, a booster dose after >6 months largely revived waning antibody signals. Epitope identity also changed after booster vaccination in some subjects, with four new S-specific epitopes detected with stronger signals after boosting than with primary vaccination. Notably, the strength of antibody responses after booster vaccination differed by the exact vaccine formulation, with variant-updated mRNA-1273.211 and mRNA-1273.617.2 booster formulations inducing significantly stronger S-specific signals than a mRNA-1273 booster. Overall, these results identify key S-specific epitopes targeted by antibodies induced by mRNA-1273 primary and variant-updated booster vaccination.