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BMC infectious diseases, 2019-03, Vol.19 (1), p.292-292, Article 292
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Syphilis-attributable adverse pregnancy outcomes in China: a retrospective cohort analysis of 1187 pregnant women with different syphilis treatment
- Ist Teil von
- BMC infectious diseases, 2019-03, Vol.19 (1), p.292-292, Article 292
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose of this study was to compare the frequency of adverse pregnancy outcomes among syphilis-seropositive women who received different treatment regimens at different times in Guangzhou, China. Pregnant women with syphilis infection who received prenatal and delivery services in Guangzhou between January 2014 and December 2016 were included. Association between treatment status and the composite adverse outcomes (preterm birth, infant smaller than gestational age, stillbirth, and spontaneous abortion) was estimated. Of 1187 syphilis-seropositive pregnant women included in the analysis, 900 (75.8%) syphilis-seropositive pregnant women received treatment, and 287(24.2%) did not receive treatment. Adverse pregnancy outcomes were observed among 16.3% (147/900) of women with treatment and 33.8% (97/287) of women without treatment. Syphilis-seropositive pregnant women treated with one or two courses of penicillin had a similar risk of adverse pregnancy outcomes (adjusted RR = 1.36, 95% CI: 0.94-1.96). Adverse outcomes were more common among women whose non-treponemal serum test titer was >1:8 and received treatment after 28 weeks compared to before 28 weeks (adjusted RR = 2.34, 95% CI: 1.22-4.48). Women who received one course of penicillin and women who received two courses of penicillin had a similar risk of adverse pregnancy outcomes. Syphilis treatment before 28 weeks of pregnancy is critical. Strategies to promote high-quality prenatal services are needed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-2334eISSN: 1471-2334DOI: 10.1186/s12879-019-3896-4Titel-ID: cdi_doaj_primary_oai_doaj_org_article_cc35749436054528a1f1e61a865f1d89
- Format
- –
- Schlagworte
- Abortion, Abortion, Spontaneous - microbiology, Adult, Adverse outcomes, Age, Anti-Bacterial Agents - therapeutic use, Birth weight, Childbirth & labor, Childrens health, China, Cohort analysis, Cohort Studies, Complications and side effects, Delivery services, Demographic aspects, Diseases, Drug therapy, Family planning, Female, Gestational Age, Health risk assessment, Health services, Health surveillance, Hepatitis, Humans, Infant, Newborn, Infection, Infections, Infectious Disease Transmission, Vertical, Maternal & child health, Miscarriage, Penicillin, Penicillins, Penicillins - therapeutic use, Pregnancy, Pregnancy complications, Pregnancy Complications, Infectious - drug therapy, Pregnancy Complications, Infectious - microbiology, Pregnancy Outcome, Pregnant women, Premature Birth, Premature infants, Prevention, Public health, Retrospective Studies, Risk factors, Sexually transmitted diseases, STD, Stillbirth, Syphilis, Syphilis - drug therapy, Syphilis - prevention & control, Syphilis - transmission, Treatment, Ultrasonic imaging, Womens health