Nature communications, 2018-05, Vol.9 (1), p.1777-14, Article 1777
- Oh, Sang Cheul
- Sohn, Bo Hwa
- Cheong, Jae-Ho
- Kim, Sang-Bae
- Lee, Jae Eun
- Park, Ki Cheong
- Lee, Sang Ho
- Park, Jong-Lyul
- Park, Yun-Yong
- Lee, Hyun-Sung
- Jang, Hee-Jin
- Park, Eun Sung
- Kim, Sang-Cheol
- Heo, Jeonghoon
- Chu, In-Sun
- Jang, You-Jin
- Mok, Young-Jae
- Jung, WonKyung
- Kim, Baek-Hui
- Kim, Aeree
- Cho, Jae Yong
- Lim, Jae Yun
- Hayashi, Yuki
- Song, Shumei
- Elimova, Elena
- Estralla, Jeannelyn S
- Lee, Jeffrey H
- Bhutani, Manoop S
- Lu, Yiling
- Liu, Wenbin
- Lee, Jeeyun
- Kang, Won Ki
- Kim, Sung
- Noh, Sung Hoon
- Mills, Gordon B
- Kim, Seon-Young
- Ajani, Jaffer A
- Lee, Ju-Seog
2018
Details
- Autor(en) / Beteiligte
- Oh, Sang Cheul
- Sohn, Bo Hwa
- Cheong, Jae-Ho
- Kim, Sang-Bae
- Lee, Jae Eun
- Park, Ki Cheong
- Lee, Sang Ho
- Park, Jong-Lyul
- Park, Yun-Yong
- Lee, Hyun-Sung
- Jang, Hee-Jin
- Park, Eun Sung
- Kim, Sang-Cheol
- Heo, Jeonghoon
- Chu, In-Sun
- Jang, You-Jin
- Mok, Young-Jae
- Jung, WonKyung
- Kim, Baek-Hui
- Kim, Aeree
- Cho, Jae Yong
- Lim, Jae Yun
- Hayashi, Yuki
- Song, Shumei
- Elimova, Elena
- Estralla, Jeannelyn S
- Lee, Jeffrey H
- Bhutani, Manoop S
- Lu, Yiling
- Liu, Wenbin
- Lee, Jeeyun
- Kang, Won Ki
- Kim, Sung
- Noh, Sung Hoon
- Mills, Gordon B
- Kim, Seon-Young
- Ajani, Jaffer A
- Lee, Ju-Seog
- Titel
- Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
- Ist Teil von
- Nature communications, 2018-05, Vol.9 (1), p.1777-14, Article 1777
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-018-04179-8Titel-ID: cdi_doaj_primary_oai_doaj_org_article_cb4f389472124edeb3126b20dcd9ed15
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - therapeutic use, Biomarkers, Cancer, Cell Line, Tumor, Chemotherapy, Chemotherapy, Adjuvant, Drug Resistance, Neoplasm, Epithelial-Mesenchymal Transition, Female, Gastric cancer, Gastrointestinal Stromal Tumors - drug therapy, Gastrointestinal Stromal Tumors - genetics, Gastrointestinal Stromal Tumors - metabolism, Gastrointestinal Stromal Tumors - pathology, Gene Expression Regulation, Neoplastic, Growth factors, Heterografts, Humans, Insulin, Integrity, Kaplan-Meier Estimate, Mesoderm - pathology, Mice, Inbred BALB C, Microsatellite Instability, Microsatellites, Mutation, Phenotypes, Prognosis, Proteomics, Receptor, IGF Type 1 - metabolism, Reproducibility of Results, Sensitivity analysis, Signal Transduction, Stomach Neoplasms - drug therapy, Stomach Neoplasms - genetics, Stomach Neoplasms - metabolism, Stomach Neoplasms - pathology, Survival, Target recognition, Therapeutic applications, Tumors