Details

Autor(en) / Beteiligte

• Girlich, Delphine
• Ouzani, Souad
• Langlois, Isabelle
• Fortineau, Nicolas
• Naas, Thierry
• Dortet, Laurent

Titel

Usefulness of Xpert® Carba-R on enrichment broth for the early detection of carbapenemase-producing Enterobacterales

Ist Teil von

• International journal of infectious diseases, 2021-11, Vol.112, p.183-185

Ort / Verlag

Canada: Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Culture-based screening of CPE using enrichment broth is sensitive but causes delay•Molecular-based screening of CPE is rapid but might miss low-level carriage•Molecular biology on enriched broth might have both sensitivity and rapidity Early detection of patients colonized with carbapenemase-producing Enterobacterales is crucial to limit their spread. Molecular biology tests are rapid but might miss low-level carriage. Culture-based methods using enrichment are cheap and detect low-level carriage but cause delay. Two clinical cases are reported, which demonstrated that molecular biology (Xpert® Carb-R) on enriched broth cumulates advantages of both strategies. In both cases, this strategy enabled early detection of patients colonized at low-level with carbapenemase-producing Enterobacterales because it saved 24 hours in detection time.