Genome Biology, 2018-11, Vol.19 (1), p.187-187, Article 187
2018
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- Autor(en) / Beteiligte
- Titel
- DNA methylation and de-methylation using hybrid site-targeting proteins
- Ist Teil von
- Genome Biology, 2018-11, Vol.19 (1), p.187-187, Article 187
- Ort / Verlag
- England: BioMed Central
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- DNA methylation plays important roles in determining cellular identity, disease, and environmental responses, but little is known about the mechanisms that drive methylation changes during cellular differentiation and tumorigenesis. Meanwhile, the causal relationship between DNA methylation and transcription remains incompletely understood. Recently developed targeted DNA methylation manipulation tools can address these gaps in knowledge, leading to new insights into how methylation governs gene expression. Here, we summarize technological developments in the DNA methylation editing field and discuss the remaining challenges facing current tools, as well as potential future directions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-760X, 1474-7596eISSN: 1474-760XDOI: 10.1186/s13059-018-1566-2Titel-ID: cdi_doaj_primary_oai_doaj_org_article_cae0f3fc3ca04615806a527d248825e1
- Format
- –
- Schlagworte
- Animals, Arthritis, Binding sites, Carcinogenesis - genetics, Cell Differentiation, CRISPR, Deoxyribonucleic acid, DNA, DNA Methylation, Epigenesis, Genetic, Epigenetics, Gene expression, Gene Expression Regulation, Genomes, Humans, Proteins, Review, Stem cells, Studies, Tumorigenesis