Details

Autor(en) / Beteiligte

• Laresgoiti-Servitje, Estibalitz
• Cardona-Pérez, Jorge Arturo
• Hernández-Cruz, Rosa Gabriela
• Helguera-Repetto, Addy Cecilia
• Valdespino-Vázquez, María Yolotzin
• Moreno-Verduzco, Elsa Romelia
• Villegas-Mota, Isabel
• Acevedo-Gallegos, Sandra
• Rodríguez-Bosch, Mario
• León-Juárez, Moisés
• Aguinaga-Ríos, Mónica
• Coronado-Zarco, Irma
• Ortiz-Calvillo, Alejandro
• Rivera-Rueda, María Antonieta
• Valencia-Contreras, Carolina
• Gómez-Sousa, María de Lourdes
• Solis-Paredes, Mario
• Rodriguez-Aldama, Juan Carlos
• Galván-Contreras, Rafael
• Figueroa-Damián, Ricardo
• Cortés-Bonilla, Manuel
• Estrada-Gutierrez, Guadalupe
• Espino-y-Sosa, Salvador
• Irles, Claudine

Titel

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

Ist Teil von

• Viruses, 2021-09, Vol.13 (9), p.1884

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2021

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• (1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.