Nature communications, 2020-11, Vol.11 (1), p.5974-5974, Article 5974
2020
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- Autor(en) / Beteiligte
- Titel
- Parabrachial nucleus circuit governs neuropathic pain-like behavior
- Ist Teil von
- Nature communications, 2020-11, Vol.11 (1), p.5974-5974, Article 5974
- Ort / Verlag
- London: Nature Publishing Group UK
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the amygdala for processing affective responses. However, it is unclear whether the LPBN actively processes neuropathic pain characterized by persistent hyperalgesia with aversive emotional responses. Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons. Optogenetic activation of GABAergic LPBN neurons does not affect basal nociception, but alleviates neuropathic pain-like behavior. Optogenetic activation of glutamatergic or inhibition of GABAergic LPBN neurons induces neuropathic pain-like behavior in naïve mice. Inhibition of glutamatergic LPBN neurons alleviates both basal nociception and neuropathic pain-like hypersensitivity. Repetitive pharmacogenetic activation of glutamatergic or GABAergic LPBN neurons respectively mimics or prevents the development of CPN ligation-induced neuropathic pain-like hypersensitivity. These findings indicate that a delicate balance between excitatory and inhibitory LPBN neuronal activity governs the development and maintenance of neuropathic pain. The parabrachial nucleus (PBN) projects to the amygdala, and contributes to affective aspects of neuropathic pain. Here the authors demonstrate that the lateral parabrachial nucleus (LPBN) contributes to hypersensitivity in a mouse model of neuropathic pain.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-020-19767-wTitel-ID: cdi_doaj_primary_oai_doaj_org_article_ca966f8a0369483dafb67a92447ca6e3
- Format
- –
- Schlagworte
- 14/19, 14/32, 42/35, 631/378/2620/410, 631/378/2620/410/2610, 64/110, 64/60, 82/51, 9/74, Amygdala, Animals, Circuits, Disease Models, Animal, Excitatory Amino Acid Agonists - pharmacology, Excitatory Postsynaptic Potentials - drug effects, Excitatory Postsynaptic Potentials - physiology, GABA Agonists - pharmacology, gamma-Aminobutyric Acid - metabolism, Glutamatergic transmission, Glutamic Acid - metabolism, Humanities and Social Sciences, Humans, Hyperalgesia, Hyperalgesia - etiology, Hyperalgesia - physiopathology, Hypersensitivity, Inhibition (psychology), Inhibitory Postsynaptic Potentials - drug effects, Inhibitory Postsynaptic Potentials - physiology, Male, Mice, Mice, Transgenic, multidisciplinary, Neural Pathways - drug effects, Neural Pathways - physiology, Neuralgia, Neuralgia - etiology, Neuralgia - physiopathology, Neurons, Neurons - drug effects, Neurons - metabolism, Nociception - physiology, Optogenetics, Pain, Pain perception, Parabrachial nucleus, Parabrachial Nucleus - cytology, Parabrachial Nucleus - drug effects, Parabrachial Nucleus - physiology, Peroneal nerve, Peroneal Nerve - injuries, Peroneal Nerve - physiopathology, Science, Science (multidisciplinary), Stereotaxic Techniques, γ-Aminobutyric acid