Details

Autor(en) / Beteiligte

• Arshad, Mohammed F.
• Alam, Aftab
• Alshammari, Abdullah Ayed
• Alhazza, Mohammed Bader
• Alzimam, Ibrahim Mohammed
• Alam, Md Anish
• Mustafa, Gulam
• Ansari, Md Salahuddin
• Alotaibi, Abdulelah M.
• Alotaibi, Abdullah A.
• Kumar, Suresh
• Asdaq, Syed Mohammed Basheeruddin
• Imran, Mohd
• Deb, Pran Kishore
• Venugopala, Katharigatta N.
• Jomah, Shahamah

Titel

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

Ist Teil von

• Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.3994

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) electrons are free to move from one bond to other bonds rendering aromatic ring properties. On account of its aromaticity, the ring has many reactive positions where donor–acceptor, nucleophilic, oxidation reactions, etc., may take place. Molecules containing a thiazole ring, when entering physiological systems, behave unpredictably and reset the system differently. These molecules may activate/stop the biochemical pathways and enzymes or stimulate/block the receptors in the biological systems. Therefore, medicinal chemists have been focusing their efforts on thiazole-bearing compounds in order to develop novel therapeutic agents for a variety of pathological conditions. This review attempts to inform the readers on three major classes of thiazole-bearing molecules: Thiazoles as treatment drugs, thiazoles in clinical trials, and thiazoles in preclinical and developmental stages. A compilation of preclinical and developmental thiazole-bearing molecules is presented, focusing on their brief synthetic description and preclinical studies relating to structure-based activity analysis. The authors expect that the current review may succeed in drawing the attention of medicinal chemists to finding new leads, which may later be translated into new drugs.