Details

Autor(en) / Beteiligte

• Luo, Chongliang
• Islam, Md. Nazmul
• Sheils, Natalie E.
• Buresh, John
• Reps, Jenna
• Schuemie, Martijn J.
• Ryan, Patrick B.
• Edmondson, Mackenzie
• Duan, Rui
• Tong, Jiayi
• Marks-Anglin, Arielle
• Bian, Jiang
• Chen, Zhaoyi
• Duarte-Salles, Talita
• Fernández-Bertolín, Sergio
• Falconer, Thomas
• Kim, Chungsoo
• Park, Rae Woong
• Pfohl, Stephen R.
• Shah, Nigam H.
• Williams, Andrew E.
• Xu, Hua
• Zhou, Yujia
• Lautenbach, Ebbing
• Doshi, Jalpa A.
• Werner, Rachel M.
• Asch, David A.
• Chen, Yong

Titel

DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models

Ist Teil von

• Nature communications, 2022-03, Vol.13 (1), p.1678-10, Article 1678

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Linear mixed models are commonly used in healthcare-based association analyses for analyzing multi-site data with heterogeneous site-specific random effects. Due to regulations for protecting patients’ privacy, sensitive individual patient data (IPD) typically cannot be shared across sites. We propose an algorithm for fitting distributed linear mixed models (DLMMs) without sharing IPD across sites. This algorithm achieves results identical to those achieved using pooled IPD from multiple sites (i.e., the same effect size and standard error estimates), hence demonstrating the lossless property. The algorithm requires each site to contribute minimal aggregated data in only one round of communication. We demonstrate the lossless property of the proposed DLMM algorithm by investigating the associations between demographic and clinical characteristics and length of hospital stay in COVID-19 patients using administrative claims from the UnitedHealth Group Clinical Discovery Database. We extend this association study by incorporating 120,609 COVID-19 patients from 11 collaborative data sources worldwide. A lossless, one-shot and privacy-preserving distributed algorithm was revealed for fitting linear mixed models on multi-site data. The algorithm was applied to a study of 120,609 COVID-19 patients using only minimal aggregated data from each of 14 sites.