Details

Autor(en) / Beteiligte

• Story-Roller, Elizabeth
• Maggioncalda, Emily C
• Cohen, Keira A
• Lamichhane, Gyanu

Titel

Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential Opportunities

Ist Teil von

• Frontiers in microbiology, 2018-09, Vol.9, p.2273-2273

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• β-lactams, the most widely used class of antibiotics, are well-tolerated, and their molecular mechanisms of action against many bacteria are well-documented. ( ) is a highly drug-resistant rapidly-growing nontuberculous mycobacteria (NTM). Only in recent years have we started to gain insight into the unique relationship between β-lactams and their targets in . In this mini-review, we summarize recent findings that have begun to unravel the molecular basis for overall efficacy of β-lactams against and discuss emerging evidence that indicates that we have yet to harness the full potential of this antibiotic class to treat infections.