Details

Autor(en) / Beteiligte

• Granata, Guido
• Petrosillo, Nicola
• Adamoli, Lucia
• Bartoletti, Michele
• Bartoloni, Alessandro
• Basile, Gregorio
• Bassetti, Matteo
• Bonfanti, Paolo
• Borromeo, Raffaella
• Ceccarelli, Giancarlo
• De Luca, Anna Maria
• Di Bella, Stefano
• Fossati, Sara
• Franceschini, Erica
• Gentile, Ivan
• Giacobbe, Daniele Roberto
• Giacometti, Enrica
• Ingrassia, Fabrizio
• Lagi, Filippo
• Lobreglio, Giambattista
• Lombardi, Andrea
• Lupo, Laura Isabella
• Luzzati, Roberto
• Maraolo, Alberto Enrico
• Mikulska, Malgorzata
• Mondelli, Mario Umberto
• Mularoni, Alessandra
• Mussini, Cristina
• Oliva, Alessandra
• Pandolfo, Alessandro
• Rogati, Carlotta
• Trapani, Filippo Fabio
• Venditti, Mario
• Viale, Pierluigi
• Caraffa, Emanuela
• Cataldo, Maria Adriana
• On Behalf Of The ReCloDi Recurrence Of Clostridioides Difficile Infection Study Group

Titel

Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections

Ist Teil von

• Journal of clinical medicine, 2021-03, Vol.10 (5), p.1127

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Limited and wide-ranging data are available on the recurrent infection (rCDI) incidence rate. We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI. Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7; 95% CI: 1.1-2.7, = 0.03). Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.