Details

Autor(en) / Beteiligte

• Papiri, Giulio
• D'Andreamatteo, Giordano
• Cacchiò, Gabriella
• Alia, Sonila
• Silvestrini, Mauro
• Paci, Cristina
• Luzzi, Simona
• Vignini, Arianna

Titel

Multiple Sclerosis: Inflammatory and Neuroglial Aspects

Ist Teil von

• Current issues in molecular biology, 2023-02, Vol.45 (2), p.1443-1470

Ort / Verlag

Switzerland: MDPI

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of mechanisms pertaining to autoimmunity, involves several key functions of immune, glial and nerve cells. The disease's natural history is complex, heterogeneous and may evolve over a relapsing-remitting (RRMS) or progressive (PPMS/SPMS) course. Acute inflammation, driven by infiltration of peripheral cells in the CNS, is thought to be the most relevant process during the earliest phases and in RRMS, while disruption in glial and neural cells of pathways pertaining to energy metabolism, survival cascades, synaptic and ionic homeostasis are thought to be mostly relevant in long-standing disease, such as in progressive forms. In this complex scenario, many mechanisms originally thought to be distinctive of neurodegenerative disorders are being increasingly recognized as crucial from the beginning of the disease. The present review aims at highlighting mechanisms in common between MS, autoimmune diseases and biology of neurodegenerative disorders. In fact, there is an unmet need to explore new targets that might be involved as master regulators of autoimmunity, inflammation and survival of nerve cells.