Details

Autor(en) / Beteiligte

• Di Lorenzo, Ritamaria
• Falanga, Danila
• Ricci, Lucia
• Colantuono, Antonio
• Greco, Giovanni
• Angelillo, Maura
• Nugnes, Fiorella
• Di Serio, Teresa
• Costa, Dorothea
• Tito, Annalisa
• Laneri, Sonia

Titel

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

Ist Teil von

• International journal of molecular sciences, 2024-04, Vol.25 (8), p.4282

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In recent years, there has been increasing interest in utilizing Traditional Chinese Medicine principles and natural bioactive compounds to combat age-related ailments and enhance longevity. A mycelium hydroethanolic extract (CsEx), which was standardized in cordycepin and adenosine using UHPLC-DAD, was investigated for its adaptogenic properties using in vitro assays and a double-blind, placebo-controlled clinical trial involving 40 subjects. The CsEx demonstrated activity at a concentration of 0.0006%, significantly increasing sirtuin expression (SirT1: +33%, SirT3: +10%, SirT6: +72%, vs. CTR, < 0.05) and NAD+ synthesis in HaCat cells (+20% vs. CTR, < 0.001). Moreover, the CsEx boosted ATP production by 68% in skin cells, correlating with higher skin energy values (+52.0% at D , < 0.01) in the clinical trial. Additionally, CsEx notably reduced cytosolic reactive oxygen species (ROS) by 30% in HaCaT cells ( < 0.05) and enhanced collagen production both in vitro (+69% vs. CTR, < 0.01) and in vivo (+10% vs. D0, < 0.01), confirmed by ultrasound examination. Furthermore, CsEx's stimulation of fibroblasts, coupled with its antioxidant and energizing properties, led to a significant reduction in wrinkles by 28.0% (D28, < 0.001). This study underscores hydroethanolic extract's potential in regulating skin cell energy metabolism and positively influencing the mechanisms associated with skin longevity control.