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Single‐cell transcriptomic analysis uncovers intratumoral heterogeneity and drug‐tolerant persister in ALK‐rearranged lung adenocarcinoma
Cancer communications (London, England), 2023-08, Vol.43 (8), p.951-955
Kwok, Hoi‐Hin
Li, Huiyu
Yang, Jiashuang
Deng, Junyang
Lee, Nerissa Chui‐Mei
Au, Timmy Wing‐Kuk
Sit, Alva Ko‐Yung
Hsin, Michael Kuan‐Yew
Ma, Stephanie Kwai‐Yee
Cheung, Lydia Wai‐Ting
Girard, Luc
Fujimoto, Junya
Wistuba, Ignacio Ivan
Gao, Boning
Minna, John Dorrance
Lam, David Chi‐Leung
2023
Details
Autor(en) / Beteiligte
Kwok, Hoi‐Hin
Li, Huiyu
Yang, Jiashuang
Deng, Junyang
Lee, Nerissa Chui‐Mei
Au, Timmy Wing‐Kuk
Sit, Alva Ko‐Yung
Hsin, Michael Kuan‐Yew
Ma, Stephanie Kwai‐Yee
Cheung, Lydia Wai‐Ting
Girard, Luc
Fujimoto, Junya
Wistuba, Ignacio Ivan
Gao, Boning
Minna, John Dorrance
Lam, David Chi‐Leung
Titel
Single‐cell transcriptomic analysis uncovers intratumoral heterogeneity and drug‐tolerant persister in ALK‐rearranged lung adenocarcinoma
Ist Teil von
Cancer communications (London, England), 2023-08, Vol.43 (8), p.951-955
Ort / Verlag
United States: John Wiley & Sons, Inc
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Abbreviations ADCs Adenocarcinomas ALDH1A1 Aldehyde dehydrogenase 1 family member A1 ALK Anaplastic lymphoma kinase CSC Cancer stem cell CCL20 Chemokine (C-C motif) ligand 20 CCR6 chemokine receptor 6 DGE Differential gene expression DTP Drug-tolerant persister EGFR Epidermal growth factor receptor EML4 Echinoderm microtubule-associated protein-like 4 ELISA Enzyme-linked immunosorbent assay FOS Fos Proto-Oncogene NANOG Homeobox protein NANOG ICAM-1 Intercellular adhesion molecule 1 IL-17 Interleukin-17 LCOs Lung cancer organoids MUC5AC Mucin-5AC NSCLC Non-small cell lung carcinoma POU5F1 POU Class 5 Homeobox 1 PROM1 Prominin 1 PTGS2 Prostaglandin-endoperoxide synthase 2 RORɣ Retinoid-related orphan receptor-γ S100A9 S100 calcium-binding protein A9 scRNA-seq Single-cell RNA sequencing TCGA-LUAD The Cancer Genome Atlas Lung Adenocarcinoma Th17 T helper-17 lymphocytes TKIs Tyrosine kinase inhibitors TNF Tumor necrosis factor UMI Unique molecular index UMAP Uniform Manifold Approximation and Projection Dear Editor, Non-small cell lung carcinoma (NSCLC) accounts for more than 85% of all lung cancers [ 1]. Differential gene expression (DGE) analysis of drug-resistant and drug-sensitive TS485T-O LCOs revealed that the interleukin-17 (IL-17) signaling pathway was enriched in both crizotinib-resistant and alectinib-resistant tumor organoids ( Supplementary Figure S2C-D). [...]we found that the actin cytoskeleton regulatory pathway was downregulated in both FA34-O crizotinib-resistant and alectinib-resistant tumor organoids ( Supplementary Figure S2E-F). Abbreviations: Anterior gradient 2 (AGR2); Chemokine (C-C motif) ligand 20 (CCL20); BPI fold containing family A, member 1 (BPIFA1); Cancer susceptibility candidate 1 (CASC1); Cell division cycle 20B (CDC20B); Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6); Cilia and flagella associated protein 126 (CFAP126); Coiled-Coil Domain Containing 170 (CCDC170); Coronin 2A (CORO2A); C-X-C motif chemokine ligand 8 (CXCL8); Dynein axonemal assembly factor 1 (DNAAF1); Dynein axonemal heavy chain 7 (DNAH7); EF-hand domain family member B (EFHB); Ferritin heavy chain 1 (FTH1); GINS complex subunit (GINS1); Hypoxia-inducible factors (HIF); Leucine Rich Repeat Containing 46 (LRRC46); Matrix metallopeptidase 1 (MMP1); Meiosis specific nuclear structural 1 (MNS1); Nicotinamide phosphoribosyltransferase (NAMPT); Nucleotide oligomerization domain (NOD); Myocardial infarction associated transcript (MIAT); Paternally Expressed 10 (PEG10); PIH1 domain containing 3 (PIH1D3); Primary cilia formation (PIFO); Prosaposin (PSAP); Ras-proximate-1 (RAP1); Radial spoke head component 1 (RSPH1); Regulator of cell cycle (RGCC); Rho family GTPase 1 (RND1); Rhophilin associated tail protein 1 like (ROPN1L); Ribosomal Protein L10 (RPL10); Insulin like growth factor binding protein 5 (IGFBP5); Intercellular adhesion molecule 1 (ICAM-1); Interleukin-17 (IL-17); S100 Calcium Binding Protein A9 (S100A9); Trefoil factor 1 (TFF-1); Tetraspanin 1 (TSPAN1); Threonine tyrosine kinase (TTK); T helper-17 lymphocytes (Th17); WAP four-disulfide core domain protein 2 (WFDC2) CCL20, mainly produced by mucosal lymphoid tissues, is a chemokine that directs lymphocyte migration toward epithelial cells.
Sprache
Englisch
Identifikatoren
ISSN: 2523-3548
eISSN: 2523-3548
DOI: 10.1002/cac2.12449
Titel-ID: cdi_doaj_primary_oai_doaj_org_article_c614af5c808441f3a89ca062943cc0a8
Format
–
Schlagworte
Adenocarcinoma of Lung - drug therapy
,
Adenocarcinoma of Lung - genetics
,
Approximation
,
Cell cycle
,
Cell division
,
Chemokines
,
Cytokines
,
Drug resistance
,
Gene expression
,
Growth factors
,
Humans
,
Kinases
,
Letter to the Editor
,
Letters to the Editor
,
Ligands
,
Lung cancer
,
Lung Neoplasms - drug therapy
,
Lung Neoplasms - genetics
,
Lung Neoplasms - pathology
,
Lymphocytes
,
Lymphoma
,
Proteins
,
Receptor Protein-Tyrosine Kinases
,
Stem cells
,
Transcriptome
,
Tumor necrosis factor-TNF
,
Tumors
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