Details

Autor(en) / Beteiligte

• Chakrabarty, Koushik
• Prashanthi, K.N.
• Shetty, Rohit
• Argulwar, Shubham
• Jeyabalan, Nallathambi
• Ghosh, Arkasubhra

Titel

Generation of iPSC line (GLNNFi001-A) from peripheral blood mononuclear cells of a patient with macular corneal dystrophy

Ist Teil von

• Stem cell research, 2022-07, Vol.62, p.102789-102789, Article 102789

Ort / Verlag

England: Elsevier B.V

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene. Here, we describe generation of a iPSC line from peripheral blood mononuclear cells (PBMCs) from a 38 year old MCD patient harboring a homozygous mutation, p.V172L in the CHST6 gene. The iPSC line GLNNFi001-A was generated using an integration-free Sendai virus containing (KLF4, c-MYC, OCT4 and SOX2).