Details

Autor(en) / Beteiligte

• D’Alessandro-Gabazza, Corina N.
• Yasuma, Taro
• Kobayashi, Tetsu
• Toda, Masaaki
• Abdel-Hamid, Ahmed M.
• Fujimoto, Hajime
• Hataji, Osamu
• Nakahara, Hiroki
• Takeshita, Atsuro
• Nishihama, Kota
• Okano, Tomohito
• Saiki, Haruko
• Okano, Yuko
• Tomaru, Atsushi
• Fridman D’Alessandro, Valeria
• Shiraishi, Miyako
• Mizoguchi, Akira
• Ono, Ryoichi
• Ohtsuka, Junpei
• Fukumura, Masayuki
• Nosaka, Tetsuya
• Mi, Xuenan
• Shukla, Diwakar
• Kataoka, Kensuke
• Kondoh, Yasuhiro
• Hirose, Masaki
• Arai, Toru
• Inoue, Yoshikazu
• Yano, Yutaka
• Mackie, Roderick I.
• Cann, Isaac
• Gabazza, Esteban C.

Titel

Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Ist Teil von

• Nature communications, 2022-03, Vol.13 (1), p.1558-1558, Article 1558

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive apoptosis of lung epithelial cells occurs in pulmonary fibrosis acute exacerbation. We recently identified corisin, a proapoptotic peptide that triggers acute exacerbation of pulmonary fibrosis. Here, we provide insights into the mechanism underlying the processing and release of corisin. Furthermore, we demonstrate that an anticorisin monoclonal antibody ameliorates lung fibrosis by significantly inhibiting acute exacerbation in the human transforming growth factorβ1 model and acute lung injury in the bleomycin model. By investigating the impact of the anticorisin monoclonal antibody in a general model of acute lung injury, we further unravel the potential of corisin to impact such diseases. These results underscore the role of corisin in the pathogenesis of acute exacerbation of pulmonary fibrosis and acute lung injury and provide a novel approach to treating this incurable disease. Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.